MIMIC Overview

MIMIC: A Multi-centre Cohort Study Evaluating the role of Inflammatory Markers in Patient’s Presenting with Acute Ureteric Colic
MIMIC has stopped recruiting new sites.


Admission to A&E is very common with over 750,000 patients admitted every year in the EU. Current practice in admitting and managing this condition is not clearly known. We would like to assess the intervention rates of patients who are admitted with acute ureteric colic and assess which tests are commonly done in their work up. Of interest is what role clinicians give to inflammatory markers in their management of patients and what imaging tests and interventions were carried out.

Aims and Objectives

Primary aims:

1. To examine whether or not there is any evidence of regional variation within the UK in the proportion of acute ureteric colic patients who undergo intervention.

Secondary aims:

1. To determine the level of association, if any, between white blood cell count (WBC count) and subsequent intervention in patients who present with acute ureteric colic.


Multi-centre national service evaluation in a 1000 patients who have previously been admitted with acute ureteric colic will have data recorded of the date of their first CT scan, the admission details including blood test results and follow up details including whether intervention or imaging was carried out. This is to be collected for patients who have already been managed by their hospital team and whose details are already stored in the trust imaging system and electronic records.

The project meets the criteria for as a service evaluation project as per the HRA online tool (see attachment below) and has also been evaluated by the R&D department at University College London Hospital and deemed as non-research.

This service evaluation will be carried out at a number of hospital sites. It is hoped that observing intervention practice and looking at variation in practice between sites may help us identify areas for service improvement.

Local Hospital Trust data management policies will be followed. No patient identifiable data will leave the original site. If any communications containing patient identifiable information are deemed necessary they will only be conducted via nhs.net email accounts or Trust email accounts.

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